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The direct impact of the COVID-19 pandemic and the indirect impact of the ensuing economic and political response have affected the United States on a large scale. We document a substantial surge in anxiety and depression symptoms from 2019 to 2020 driven by the young adult population, indicating a disproportional indirect impact on the young. Multivariate regression analysis was utilized to quantify the stringency of state responses’ indirect effect on the changes in anxiety or depression symptoms during the pandemic. While we observe a slight decline in the share of the adult population experiencing anxiety and depression through July 2021- June 2022, such decline does not compensate for the large surge of mental health issues among young adults in 2020. Overall, our results indicate that the effects of the stringency of the mitigation measures on different areas of health are complex and vary by state, with a wide variation of mental health-related issues by age group and a higher prevalence in younger adult age categories. After discussing inequities in the accessibility of mental health treatment, lack of health insurance, and implications for quality of life among young adults, this paper adds to the breadth of ongoing COVID-19 research and emphasizes the importance of considering the overall health of the population in a large-scale health crisis as well as discussing the potential unintended consequences of the mitigation measures put in place.